Endoscopic Botulinium Toxin-A Application In The Treatment of Obesity: The Effect Of Dose And Application Area On Treatment Success

Abstract

Introduction: In this study, it was aimed to examine the effect of dose and region on the effectiveness of Endoscopic Botulinum toxin A application in the fight against obesity. Material and Method: A total of 446 patients who applied to our clinic with the complaint of weight were included in the study. Endoscopic Botulinum toxin A was administered at doses of 300 U (n=74), 400 U (n=172) and 500 U (n=200) according to the weight and Body Mass Index (BMI) values of the patients. Patients were divided into three groups in the Preploric, Cardia and Fundus regions, after 125 U of Endoscopic Botulinum toxin A application to each region, and 125 U application to one region. Results: Initial BMI, weight difference, last BMI and BMI differences were statistically significant between patient groups according to dose and area (p<0.05). All BMI differences between paired dose and area groups were statistically significant (p<0.05). BMI difference was significantly correlated with gender (r=0.108; p<0.05), Initial BMI (r=0.266; p<0.01), weight (r=0.219; p<0.01), dose (r=0.834; p<0.01), and area (r=0.200; p<0.01). Effects of initial BMI (B=0.031; p<0.05), dose (B=1.423; p<0.01) and area (B=0.316; p<0.01) on BMI difference were statistically significant. Conclusion: Optimum results are obtained in the application of fundus region with a density of 500 U in total, but at levels or values below this, the results may not be effective. Weight loss with the Endoscopic Botulinium toxin-A method with the appropriate dose and area is an effective and usable method in the fight against obesity.