Factors which modulate the rates of skeletal muscle mass loss in non-small cell lung cancer patients: a pilot study.

Abstract

Advanced non-small cell lung cancer (NSCLC) is associated with weight loss which may reflect skeletal muscle mass (SMM) and/or total adipose tissue (TAT) depletion. This study aimed to describe changes in body composition (BC) parameters and to identify the factors unrelated to the tumor which modulate them. SMM, TAT, and the proportion of SMM to SMM+TAT were assessed with computed tomography. Estimates of each BC parameter at follow-up initiation and across time were derived from a mixed linear model of repeated measurements with a random intercept and a random slope. The same models were used to assess the independent effect of gender, age, body mass index (BMI), and initial values on changes in each BC parameter. Sixty-four patients with stage III or IV NSCLC were reviewed. The mean±SD decreases in body weight and SMM were respectively 59±3g/week (P<0.03) and 7mm2/m2/week (P=0.0003). During follow-up, no changes were identified in TAT nor in muscle density or in the proportion of SMM to SMM+TAT, estimated at 37±2% at baseline. SMM loss was influenced by initial BMI (P<0.0001) and SMM values (P=0.0002): the higher the initial BMI or SMM values, the greater the loss observed. Weight loss was greater when the initial weight was heavier (P<0.0001). Our results demonstrate that SMM wasting in NSCLC is lower when initial SMM and BMI values are low. These exploratory findings after our attempt to better understand the intrinsic factors associated with muscle mass depletion need to be confirmed in larger studies.