Abstract
Objective: The aim of this trial was to determine whether endometrial scratch-suction caused by insertion tube of (IUCD) with suction improved the probability of pregnancy in the subsequent IVF cycle in patients who had previous failed IVF outcome by removing small polyps and any hazardous materials. Design: Observational prospective cohort experimental study. Setting: Zagazig University Hospital, Obstetrics and Gynecology department. From period between September 2011 till September 2012. Population: 30 patients with previous failed IVF despite transfer of goodquality embryos were allocated to endometrial scratch-suction in the same the cycle of embryo transfer. Methods: From day 5 to day 7 of same ICSI cycle, the patients in study underwent endometrial scratch-suction technique. After preparation of insertion tube of (IUCD) and infant feeding tube 8 F, moving the insertion tube of IUCD from below upwards with scratching anterior uterine wall, then posterior, then left lateral uterine wall, then right lateral uterine wall, then fundus, all these steps are associated with suction by attaching proximal end of infant feeding tube 8 F to suction apparatus. Main Outcome Measures: Implantation and clinical pregnancy rates. Results: The implantation occurred in 24/30 (80%). The clinical pregnancy occurred in 20/30 patients (66.66%). 12/30 patients (40%) during scratch-suction technique had small fleshy masses obstructing suction tube which were small endometrial polyps. Conclusions: Endometrial scratch-suction improves clinical pregnancy and implantation rates in the same IVF-ET cycle in patients with previous unsuccessful IVF cycles.
Highlights
The process of implantation still remains a limiting factor in in vitro fertilization (IVF)-ET
The clinical pregnancy occurred in 20/30 patients (66.66%). 12/30 patients (40%) during scratch-suction technique small fleshy masses obstructed suction tube and were small endometrial polyps
In this observational prospective cohort experimental study trial including 30 patients with previous failed IVF despite transfer of good-quality embryos were allocated to endometrial scratch-suction in the same the cycle of embryo transfer
Summary
The process of implantation still remains a limiting factor in IVF-ET. For implantation to occur, a geneticallyHow to cite this paper: Nossair, W.S., et al (2014) Endometrial Scratch-Suction and Implantation Failure. The findings suggest that a Th1 inflammatory response is necessary for the acquisition of uterine receptivity This notion was originally suggested by reports from many clinical centers worldwide that IVF patients with repeated implantation failure subjected to endometrial biopsy exhibit a substantial improvement in their chances to conceive. These findings, followed by the demonstration of an elevated pro-inflammatory cytokine/chemokine expression, as well as an increased abundance of immune cells, in the endometrium of these patients, raised the idea that the acquisition of uterine receptivity is closely associated with an inflammatory response. No benefit from local injury to the endometrium in women with a high number of RIFs [3]
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