Year-end Sale % OFF 
Abstract
Ovarian steroid-regulated cyclical regeneration of the endometrium is crucial for endometrial receptivity and embryo implantation, and it is dependent on the dynamic remodeling of the endometrial vasculature. Perivascular cells, including pericytes surrounding capillaries and microvessels and adventitial cells located in the outermost layer of large vessels, show properties of mesenchymal stem cells, and they are thus promising candidates for uterine regeneration. In this review, we discuss the structure and functions of the endometrial blood vasculature and their roles in endometrial regeneration, the main biomarkers and characteristics of perivascular cells in the endometrium, and stem cell-based angiogenetic therapy for Asherman’s syndrome.
Highlights
During a woman’s reproductive years, the endometrium dynamically undergoes around 400 cycles of morphological and functional changes, and the cyclic change of the endometrium is crucial for embryo implantation
The functional layer uniquely goes through extensive proliferation and slough, while the basal layer does not shed during each menstrual cycle
SUSD2, another marker of perivascular cells that possesses MSC properties, is expressed mostly in the tunica media of vessels and in only a small proportion of CD34+ adventitial cells (Figure 2c). Both CD34+ adventitial cells and CD146+ pericytes derived from the human endometrium, could differentiate into endometrial stromal-like cells, while the expression levels of vimentin and CD13 significantly increased in adventitial cells [47]
Summary
During a woman’s reproductive years, the endometrium dynamically undergoes around 400 cycles of morphological and functional changes, and the cyclic change of the endometrium is crucial for embryo implantation. Thereafter, the functional layer grows from the basal layer and is repaired in response to the rebound of estrogen in the proliferative phase [2]. This process is regulated by ovarian steroids and accompanied by angiogenesis and vessel regression. Ture, This and review examines how blood vessels vary in response to the cyclic change in vasculaovarian introduces the development and structure of the endometrial steroids. Tential and underlying mechanisms of uterine repair based on perivascular cells in the with limited applications in both animal and clinical trials, the regenerating treatment of severe (AS). Potential and underlying mechanisms of uterine repair based on perivascular cells in the treatment of severe Asherman’s syndrome (AS) or IUA are discussed
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
