ENDOECOLOGICAL MODEL OF RELATIONSHIP BETWEEN LIVER DYSFUNCTION AND LARGE INTESTINE DYSBIOSIS IN ACUTE ALCOHOLIC PSYCHOSIS

Abstract

The results of biochemical parameters evaluation of blood dynamics and large intestine endoecology in patients with a syndrome of dependence on alcohol are presented. Friendly changes in enzymatic activity of blood serum and quantitative content of the main microflora representatives of large intestine in patients with acute alcoholic psychosis (AAP) are identified. It was produced ranking indicators of serum enzymes, lipids, pigment metabolism with subsequent calculation of the deviations from the physiological norm limits. The total degree of deviation indicators was considered as independent variables, the relationship that reflects a comprehensive assessment of the functional state of the liver to the extent that the large intestine dysbiosis. A mathematical model of regression-type complex quantitative estimation of biochemical status and microbiocenosis rectum at the AAP, based on the scale level, which reflects the cumulative severity of the patient's existing endoecological violations in the values of the analyzed parameters is made. Dynamics assessment of analyzed indicators changes in the course of treatment has allowed to identify the most important biochemical and microbiological parameters for future inclusion as predictors of liver disease progression risk in the development in a mathematical model of the relationship reducing the effectiveness of liver detoxification and dysbiotic shifts the large intestine microflora. The proposed approach can be used to facilitate the evaluation of the recovery of liver function in the process of the treatment on the level of the share of the mutual influence of the recovery in the intestinal microbiocenosis quantitative variables.