Features of the «microbial landscape» of the pharynx and large intestine in patients with chronic compensated tonsillopharyngitis

Abstract

Оbjective : analysis of microbiocenosis of the upper respiratory tract and large intestine in patients with chronic compensated tonsillopharyngitis. Materials and methods: was carried out an analysis of a retrospective study of the microbiocenosis of the upper respiratory tract and large intestine was carried out in 126 patients with chronic compensated tonsillopharyngitis. The control group consisted of 25 apparently healthy people. To characterize the local immunity of the mucosa of the pharynx and large intestine, the content of pro-inflammatory (IL-1β, IL-2, IL-6, IL-8) and anti-inflammatory (IL-4, IL-10) cytokines in the coprofiltrates of patients with chronic compensated tonsillopharyngitis was determined by enzyme immunoassay. Results : in patients with chronic compensated tonsillopharyngitis, marked disturbances were registered in the microbiocenoses of the upper respiratory tract (with a predominance of β-hemolytic streptococci and fungi Candida , recorded in 66.7% and 48.4% of patients, respectively) and the large intestine (with a moderate decrease in the content of bifidobacteria to lg 8.0 ± 0.2, lactobacilli up to lg 6.3 ± 0.15, as well as the total number of Escherichia up to lg 6.4 ± 0.2), as well as an imbalance of cytokines (a significant increase in the content of the pro-inflammatory cytokine IL-2, a moderate increase pro-inflammatory cytokine IL-10) and a significant (more than 15 times) increase in local synthesis of γ-interferon. Conclusions : the results of this study may indicate the translocation of microbes and their toxins into the internal environment of the body, which causes a decrease in immunoreactivity and the development of chronic systemic inflammation. These data should be taken into account in the development and comprehensive clinical and pharmacological evaluation of new drugs for the treatment of chronic compensated tonsillopharyngitis.