Abstract
Endocytic vesicles isolated from rabbit reticulocytes contained an intrinsic Ca 2+-pump activity that was dependent on ATP, activated by calmodulin and inhibited by vanadate. 45Ca 2+ uptake and acidification studies indicated that acidification of the endocytic vesicles inversely correlated with the Ca 2+-pump activity. Acidification was inhibited by externally added Ca 2+ and calmodulin and activated by vanadate and EGTA. It is suggested that intravesicular Ca 2+ can act as a modulator of endocytic vesicle acidification.
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