Abstract
The dodecahydro-phenanthrene derivative, 2-acetyl-7-oxo-l,2,3,4,4a, 4b,5,6,7,9,10,10a-dodecahydro-phenanthrene, has been shown in previous studies to manifest androgenic, anabolic, antiandrogenic and antigonadotropic activities. The dextro and the levo enantiomers of this phenanthrene derivative have been prepared, and both have been tested for endocrine activity concurrently with the racemate. The results obtained indicate that the dextro enantiometer is responsible for the androgenic, the anabolic, the antiandrogenic and the antigonadotropic activities of the racemate, and that the levo enantiometer is inactive.
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