Abstract
Endocannabinoids as Markers of Sperm Quality: Hot Spots
Highlights
Human sperm express CB1, and its activation by AEA affects motility and acrosome reaction (AR)
Human sperm exposure to methanandamide, a non-hydrolyzable analog of AEA, has been shown to significantly decrease mitochondrial transmembrane potential without triggering any mitochondria-dependent apoptotic death, and such an effect was prevented by the CB1 antagonist SR141716, but not by the CB2 antagonist SR144528, nor by the transient receptor potential vanilloid 1 (TRPV1) antagonist iodoresiniferatoxin [7]
In the presence of glucose human sperm exposure to methanandamide for up to 18 h failed to affect sperm motility, that instead was dramatically reduced by the same substance under glycolysis blockage; again, the latter effect was prevented by SR141716 [7]
Summary
Human sperm express CB1, and its activation by AEA affects motility and acrosome reaction (AR). Human sperm exposure to methanandamide, a non-hydrolyzable analog of AEA, has been shown to significantly decrease mitochondrial transmembrane potential without triggering any mitochondria-dependent apoptotic death, and such an effect was prevented by the CB1 antagonist SR141716, but not by the CB2 antagonist SR144528, nor by the TRPV1 antagonist iodoresiniferatoxin [7].
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