Abstract
ABSTRACTIn this study, the fabrication of almond gum/polyvinyl alcohol (PVA) composite nanofibers loaded with curcumin or its β-cyclodextrin inclusion complex (βCDIC) using electrospinning process was studied. The preparation of inclusion complex was done using freeze drying method. The characterization of electrospun nanofibers was studied by FESEM, XRD, TGA and FTIR analysis. FESEM results showed that the fiber diameters were in the range of 98–169 nm. XRD analysis indicated the crystalline aggregates of curcumin in the fiber matrix, whereas curcumin-βCDIC did not show crystalline aggregates. Thermal stability of nanofibers increased after incorporation of curcumin and curcumin-βCDIC into them. FTIR analysis confirmed the formation of the complex between curcumin and βCD. The solubility of curcumin and curcumin-βCDIC incorporated into nanofibers were increased up to 70 and 160 times compared with pure curcumin, respectively. The results showed that almond gum nanofibers can be used as a suitable carrier for hydrophobic compounds to enhance their solubility for application in the food and pharmaceutical industries.
Highlights
Curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadien-3,5-dione] is a hydrophobic polyphenolic pigment which is found in the rhizomes of the plant Curcuma longa
The crystalline peaks of curcumin do not appear in the X-ray diffraction (XRD) pattern of almond gum/Polyvinyl alcohol (PVA)/curcuminβCDIC nanofibers while in the XRD pattern of almond gum/PVA/curcumin the sharp peak of curcumin in 2θ≈ 15o appear. These results indicate that the true inclusion complexation between curcumin and βCD is kept even after the electrospinning process
Field emission scanning electron microscope (FESEM) results showed that the almond gum/ PVA solutions containing curcumin-β-cyclodextrin inclusion complex (βCDIC) produced nanofibers with the lower diameter in comparison of the almond gum/PVA solutions containing pure curcumin
Summary
Curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadien-3,5-dione] is a hydrophobic polyphenolic pigment which is found in the rhizomes of the plant Curcuma longa. The incorporation of curcumin in different carriers or delivery system can prevail to these limitations
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