Abstract
Inclusion complex of β-cyclodextrin (β-CD) and Plai (Zingiber cassumunar) oil was prepared using a simple co-precipitation method at β-CD to Plai oil in different ratios. The inclusion complexes were characterized using Fourier transform-infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC). The FT-IR absorption bands of inclusion complex at 3600-3200 cm-1 were broader and shifted toward lower frequencies compared with that of pure β-CD (3359 cm-1). DSC of the inclusion complexes showed two endothermic peaks shifted to lower temperatures (90-100°C and 295-300°C) compared to that of β-CD. The different physicochemical characteristic could be an indication of an embedded guest molecule in the β-CD cavities in the inclusion complex preparation.
Highlights
In the latest year, cyclodextrin (CD) complexation has been effectively used to improve the solubility and stability of a number of poorly water-soluble compounds
CD has a hydrophilic rim and a lipophilic interior [2] and with this specific structure, it possesses an ability to form host-guest inclusion complexes with many lipophilic compounds [3]
Preparation of Plai oil-β-CD inclusion complex The complex of Plai oil and β-CD was prepared by using a co-precipitation method. β-CD 5.0 g
Summary
Cyclodextrin (CD) complexation has been effectively used to improve the solubility and stability of a number of poorly water-soluble compounds. CD has a hydrophilic rim and a lipophilic interior [2] and with this specific structure, it possesses an ability to form host-guest inclusion complexes with many lipophilic compounds [3]. This property has received extensive attention in the pharmaceuticals and cosmetics to improve the water solubility, stability, dissolution and release rates of various active molecules [4,5]. Zingiber cassumunar Roxb., ( called “Plai” in Thailand) is a medicinal plant widely cultivated in Thailand and tropical Asia. Cyclodextrin (CD) complexation is one method to deliver oil-soluble into water base system. The inclusion complexes were characterized using Fourier transform-infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC)
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