Enantioselective syntheses of ( R)- and ( S)-argentilactone and their cytotoxic activities against cancer cell lines

Abstract

Concise total syntheses of ( R)- and ( S)-argentilactone have been developed via enantioselective catalytic allylation (ECA) and ring-closing metathesis pathways (four steps, 39% overall yield and 82–84% ee) from 2-octynal and their in vitro activity against cancer cells is described.