Abstract
Abstract Extracts from 27 marine algal species (14 Rhodophyta, 5 Phaeophyta and 8 Chlorophyta) from the Yucatan peninsula (Mexico) were evaluated for cytotoxic and anti-roliferative activity by 3[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT) and sulforhodamine B (SRB) assays, respectively. In order to determine the specificity of the cytotoxic activity on tumor cells selective index (SI) was also calculated. The following cancer cell lines were employed: normal canine kidney cells (MDCK), human laryngeal carcinoma (Hep-2), human cervix adenocarcinoma (HeLa) and human nasopharynx carcinoma (KB). The results indicated that 44 and 51% of algal species tested showed cytotoxic and anti-roliferative activity, respectively. Most of the cytotoxic extracts were species belong to Chlorophyta, Udotea flabellum and Udotea conglutinate showed the highest cytotoxic activity on all cancer cell lines. For Rhodophyta, the extract of Bryothamnion triquetrum showed an outstanding selective cytotoxicity against Hep-2 cells (CC50 8.29 µg mL−1 with SI=12.04). Two out of five species of Phaeophyta tested (Lobophora variegata and Dictyota caribaea) showed high cytotoxicity activity on KB cell line. The data show that these extracts are potential source of compounds for prevention of certain cancer diseases. Citation Information: Cancer Prev Res 2010;3(1 Suppl):B78.
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