Abstract
AbstractN‐Deprotonated five‐, six‐, seven, and nine‐membered lactams undergo smooth palladium‐catalyzed N‐allylation with methyl‐(pent‐3‐en‐2‐yl)‐carbonate or 2‐chloro‐3‐pentene. With axially chiral bisphosphane ligands, enantioselectivities ranging from 83 to 97% ee are reached. The configuration of one of the allylation products is assigned unambiguously by the preparation of a relay compound and by analogy to the others. Using the enantioselective allylation protocol as a key step, δ‐valerolactam is converted into (4S,9aR)‐4‐methylquinolizidine.
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