Abstract
AbstractThe metallo‐organocatalyzed enantioselective synthesis of various five‐membered carbo‐ and heterocyclic structures through the merger of aminocatalysis with the catalytic indium(III) or copper(I) activation of α‐disubstituted formyl alkynes is described. The use of indium trichloride associated with the (R)‐1,1′‐bis‐(2‐naphthylamine) ligand led to encouraging results with up to 85:15 enantiomeric ratio. After a careful examination of several other strategies, the best synergic catalytic system, which combines a chiral copper(I) complex with cyclohexylamine, afforded the enantioselective preparations of cyclopentane, indane, and pyrrolidine scaffolds with moderate to excellent control of the all‐carbon quaternary stereogenic centers created through such cyclization processes.
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