Abstract
The direct separation of the enantiomers of diltiazem and its three chloro derivatives, including clentiazem, was investigated by capillary zone electrophoresis (CZE) and electrokinetic chromatography (EKC) using polysaccharides. An electrically neutral beta-cyclodextrin polymer, dextran sulfate, and mucopolysaccharides, such as heparin and chondroitin sulfate C, were employed as chiral selectors. Among the tested solutes, 8-chlorodiltiazem (clentiazem) was well enantiorecognized by the methods. Affinity electrokinetic chromatography (AEKC) using chondroitin sulfate C was the most successful; all tested solutes were completely enantioseparated by this mode.
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