Abstract
The subcritical fluid chromatographic separation of three enantiomeric pairs of phosphine oxides (two phosphanorbornadienes and 1,2,5-triphenylphospholane-1-oxide) was performed on a pilot plant equiped with a 60-mm axial compression column packed with Pirkle-type phases, the mobile phase being carbon dioxide-ethanol mixtures. With selectivities ranging from 1.1 to 1.3, both enantiomers were obtained with an optical purity greater than 95%. The resolution of one phosphanorbornadiene pair was optimized with a production rate reaching 510 mg/h with a good yield (80%).
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