Abstract
En-Bloc Transurethral Resection of Non-Muscle-Invasive Bladder Cancer. Current Evidence and Glimpses into the Future
Highlights
Standard treatment of non-muscle-invasive bladder cancer (NMIBC) consists of transurethral resection of the tumor (TURB) with adjuvant intravesical instillation therapy, when needed, according to the tumor risk of recurrence and progression [1,2]
Conclusion: en-bloc TURB (eTURB) seems to provide a significant improvement in the surgical management of NMIBC with regards to oncology and safety outcomes
Two recent systematic reviews showed that residual tumor at re-TURB can be found in up to 67% of patients with Ta and in up to 71% with T1 BC, even if muscle was present in the initial specimen [13,14].In contrast, a retrospective multicenter analysis reported only 6.4% of residual cancer at re-TURB after en-bloc TURB for highrisk NMIBC [15]
Summary
Standard treatment of non-muscle-invasive bladder cancer (NMIBC) consists of transurethral resection of the tumor (TURB) with adjuvant intravesical instillation therapy, when needed, according to the tumor risk of recurrence and progression [1,2]. Two recent systematic reviews showed that residual tumor at re-TURB can be found in up to 67% of patients with Ta and in up to 71% with T1 BC, even if muscle was present in the initial specimen [13,14].In contrast, a retrospective multicenter analysis reported only 6.4% of residual cancer at re-TURB after en-bloc TURB (eTURB) for highrisk NMIBC [15]. The purpose of this review was to summarize the current evidence on en-bloc transurethral resection (eTURB) of non-muscle-invasive bladder cancer compared to conventional TURB (cTURB) with a particular emphasis on ongoing randomized trials
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