Abstract
Aims: Deep brain stimulation (DBS) of the anterior cingulate cortex (Cg25 area) is currently investigated as an alternative treatment in treatment resistant patients with major depressive disorder. This area has been shown overactive in depressive patients using PET. Here, we use direct recordings of local field potential (LFP) activity during presentation of emotionally laden pictures to evaluate the involvement of Cg25 area in affective processing. Methods: Three female patients with treatment resistant major depression underwent bilateral implantation of DBS electrodes in the Cg25 area. LFP were recorded during presentation of neutral, pleasant and unpleasant pictures from the international affective picture system. FFT-based power spectra and event-related desynchronisation (ERD) of oscillatory activity were evaluated separately for each emotional category and correlated with the individual Hamilton depression score (24 items, HAM-D) at baseline and 2 yrs follow-up.
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