Activation of the subthalamic region during emotional processing in Parkinson’s disease: insights from intracranial recordings

Abstract

Event Abstract Back to Event Activation of the subthalamic region during emotional processing in Parkinson’s disease: insights from intracranial recordings Andrea A. Kuehn1* 1 Charité-University Medicine Berlin, Germany Deep brain stimulation (DBS) of the subthalamic nucleus (STN) leads to affective disturbances in about 14% of patients with Parkinson’s disease (PD; Temel et al., 2006). It is likely that some of the behavioural complications are the direct consequences of STN DBS since mood changes can be influenced by changes in stimulation parameters and deficits in facial discrimination of negative emotions have been observed after STN stimulation in PD. We directly recorded local field potential (LFP) activity from deep brain electrodes in PD patients during viewing of emotionally arousing and neutral pictures, selected from the International Affective Picture System (IAPS). A significantly larger event-related desynchronization (ERD) in the alpha frequency range occurred 1-2s after stimulus presentation of emotionally salient pictures as compared to neutral stimuli. Moreover, the alpha ERD was correlated with the individual valence rating of the pleasant stimuli, suggesting that emotional information processing at the level of the STN may be related to valence discrimination processes. The modulation of neuronal response pattern was dependent on dopamine in PD, with decreased reactivity of alpha activity after dopamine withdrawal, possibly related to abnormal processing in the limbic cortex-basal ganglia loop. Together, our findings show that the STN is active during emotional processing in PD patients as indexed by modulation of STN LFP alpha activity and that the activation pattern is modulated by valence of the stimuli and dopaminergic activation. Conference: 10th International Conference on Cognitive Neuroscience, Bodrum, Turkey, 1 Sep - 5 Sep, 2008. Presentation Type: Oral Presentation Topic: Abstracts Citation: Kuehn AA (2008). Activation of the subthalamic region during emotional processing in Parkinson’s disease: insights from intracranial recordings. Conference Abstract: 10th International Conference on Cognitive Neuroscience. doi: 10.3389/conf.neuro.09.2009.01.024 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Nov 2008; Published Online: 27 Nov 2008. * Correspondence: Andrea A Kuehn, Charité-University Medicine Berlin, 82152 Planegg-Martinsried, Germany, Andrea.kuehn@charite.de Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Andrea A Kuehn Google Andrea A Kuehn Google Scholar Andrea A Kuehn PubMed Andrea A Kuehn Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.