Abstract
The recent outbreak of Elizabethkingia anopheles in Midwest countries has caused a number of deaths. Notably Elizabethkingia anopheles causes neonatal meningitis, bacteraemia, sepsis, blood stream infections and respiratory infections. This infection may pose serious threats to public health because of lack of sufficient research and its endemic potential unknown.
 This systematic review was meant to develop a deeper insight into the current status of E. anophelis related evidence and to highlight areas that need further research. Reviewing existing literature will help other researchers in identifying and addressing the knowledge gaps.
 Various free access databases such as Google Scholar, Scopus, PubMed, and Science Direct were employed for literature survey. All articles that have been published since 2011, when the outbreak was reported for the first time have been included in this systematic review. The research related to this subject is in earlier stages and little information is currently available. Future studies must focus on the molecular basis, control, prevention, and therapeutics of E. anophelis infection to mitigate its increasing risk. This review is meant to provide baseline data for future research. Scientific community must carry out research on infections caused by E. anophelis mosquito else it will result in a disastrous outbreak.
Highlights
Genus Elizabethkingia is a part of family Flavobacteriaceae and phylum Bacteroidetes
Four different species that belong to the genus Elizabethkingia are E. miricola, E. meningoseptica, E. endophytica, and E. anophelis
Specific resistance dynamically meningitis E. anophelis genes acquired as a result evolving over isolates compared with of horizontal transfer were time
Summary
Genus Elizabethkingia is a part of family Flavobacteriaceae and phylum Bacteroidetes. It is a non-motile, ubiquitous, and aerobic bacterium mostly found in the gut of Anopheles mosquito and colonizes the human respiratory tract. Four different species that belong to the genus Elizabethkingia are E. miricola, E. meningoseptica, E. endophytica, and E. anophelis. E. meningoseptica is a nosocomial pathogen that affects patients on hemodialysis [1, 2] and is responsible for bacteremia [3], septicaemia [4], endophthalmitis [5], and meningitis [2, 69]. E. miricola has the potential to cause ventilator associated pneumonia, sepsis, and bacteremia [10, 11]. Phylogenetic analysis revealed that E. anophelis is different from the closely related species E. miricola and the related group E. meningoseptica (Figure 1)
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