Abstract
Emerging immune functions of non-hematopoietic stromal cells.
Highlights
One of the earliest motives that have fueled the study of immune stroma has been the interest in immune system development and the quest to define the action of a set of molecules required for primary and secondary lymphoid organ formation (5, 6)
Some effects were radical leading to a total absence or lymphoid organs, whereas some were mild, resulting in the reduction of a subset of hematopoietic cells such as B cells owing to the absence of follicular dendritic cells
Communication systems between fibroblasts may be used by hematopoietic cells, or messages sent by stromal cells may be read by a subset of hematopoietic cells
Summary
One of the earliest motives that have fueled the study of immune stroma has been the interest in immune system development and the quest to define the action of a set of molecules required for primary and secondary lymphoid organ formation (5, 6). Some effects were radical leading to a total absence or lymphoid organs, whereas some were mild, resulting in the reduction of a subset of hematopoietic cells such as B cells owing to the absence of follicular dendritic cells.
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