Abstract

This article highlights the very recent advances in glycopolypeptide synthesis via NCA polymerization and first studies on stimuli-responsive solution behavior and self-assembling structures. Yet glycopolypeptides are almost exclusively considered as smart biofunctional materials for use in biomedical applications, for instance in targeted drug delivery, but also have high potential for usage as structural materials to fabricate bioinspired hierarchical structures.

Highlights

  • Bioinspired or biohybrid polymers are an emerging class of materials that are designed to combine advantageous features of synthetic polymers, such as solubility, processability, and scalability, with those of biological entities like chirality, selective recognition, or signaling.[1,2] Recent efforts have been focused on sugar-containing polymers, including carbohydratesynthetic copolymers, block copolymers, and polymers with pendant carbohydrates – the latter being usually referred to as glycopolymers.[3]Since the rst reported examples in the early 1960s,4–6 many different glycopolymers have been produced by free orMax Planck Institute of Colloids and Interfaces, Department of Colloid Chemistry, Research Campus Golm, 14424 Potsdam, Germany

  • Comprehensive and more detailed information can be found in a number of excellent reviews and perspectives that have been published in the last year.[18,19,20,21,22]

  • Just one study has been reported on the use of glycopolypeptide block copolymers, more on glycopeptide dendrimers,[63,64] for targeted drug delivery

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Summary

Introduction

Bioinspired or biohybrid polymers are an emerging class of materials that are designed to combine advantageous features of synthetic polymers, such as solubility, processability, and scalability, with those of biological entities like chirality, selective recognition, or signaling.[1,2] Recent efforts have been focused on sugar-containing polymers, including carbohydratesynthetic copolymers, block copolymers, and polymers with pendant carbohydrates – the latter being usually referred to as glycopolymers.[3]. He joined the group of Helmut Schlaad at the Max Planck Institute of Colloids and Interfaces in Potsdam, Germany, to pursue a doctoral degree which he obtained with honors (summa cum laude) in 2013. A er a one year post-doctoral fellowship with Rudolf Faust at the University of Massachusetts in Lowell, USA, he moved to the Max Planck Institute of Colloids and Interfaces in Potsdam, Germany. He nished habilitation, mentored by Markus Antonietti, and became a senior scientist in 2004. Comprehensive and more detailed information can be found in a number of excellent reviews and perspectives that have been published in the last year.[18,19,20,21,22]

Synthesis of glycopolypeptides
Post-polymerization glycosylation of synthetic polypeptides
Aqueous solution and selfassembly behavior
Stimuli-responsive behavior
Self-assemblies in aqueous solution
Biological applications
Findings
Summary and outlook

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