Abstract
Emerging Applications of Metabolomics in Drug Development
Highlights
Metabolomics is a relatively new discipline in contrast to other well-established omics such as genomics, transcriptomics, and proteomics
The metabolic insights on diseases and drug efficacy could facilitate the discovery of novel therapeutic biomarkers of diseases that are of critical significance for drug discovery
Drug efficacy or metabolismassociated metabolic phenotypes open up an important window for performing precise clinical trial of either “old” or novel drug candidates
Summary
Metabolomics is a relatively new discipline in contrast to other well-established omics such as genomics, transcriptomics, and proteomics. The metabolic insights on diseases and drug efficacy could facilitate the discovery of novel therapeutic biomarkers of diseases that are of critical significance for drug discovery. Tremendous efforts have been paid to discovery of novel drug targets by over whelmingly focus on genetic aspect, the successful cases were far less than expected because most diseases are consequences of complicated interactions between genetic and environmental factors (e.g gut microbiome and epigenome).
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