Abstract
The amount of embryonic antigens (EA) was estimated in 13 BALB/c fibrosarcomata by in vitro cell mediated cytotoxicity of anti-embryo spleen cells and by quantitative absorption of an anti-embryo antiserum. A direct relationship between amount of EA and tumour growing capacity was found. EA were detected also on fast dividing testicular cells. It is suggested that EA expression on tumour cells is related to a cell membrane function controlling mitosis rather than to a function specifically related to the neoplastic status. Tumour take of low doses of 2 EA-bearing sarcomata was found to be enhanced in anti-embryo immune BALB/c mice in comparison with that in normal and anti-fibroblast immune mice.
Highlights
Summary.-The amount of embryonic antigens (EA) was estimated in 13 BALB/c fibrosarcomata by in vitro cell mediated cytotoxicity of anti-embryo spleen cells and by quantitative absorption of an anti-embryo antiserum
In a previous experiment (Menard et al, 1973) we demonstrated that expression of EA on DMBA induced murine fibrosarcomata increased during serial transplant in syngeneic host
Fibrosarcomata were induced in BALB/c mice by subcutaneous implantation of a teflon disc 15 mm in diameter, by a single subcutaneous injection of 50,ug of 7,12-dimethylbenz(a)anthracene (DMBA) in oil suspension, by exposing to 3-methylcholanthrene (MCA) BALB/c normal fibroblasts in diffusion chambers inserted in the abdominal cavity of BALB/c mice (Parmiani, Carbone and Lembo, 1973), and by spontaneous transformation of BALB/c normal fibroblasts in in vitro long-term culture (Carbone, Piazza and Parmiani, 1974)
Summary
THE PRESENCE of embryonic antigens (EA) on tumours induced by different agents has been demonstrated in various animal species and it has been ascertained that such antigens differ both from the individual ones which characterize chemically induced ttumours (Baldwin, Glaves and Vose 1972; Menard, Colnaghi and Della Porta, 1973; Thomson and Alexander, 1973) and from the cross-reacting antigens carried by viral tumours (Ting et al, 1972; Kurth and Bauer, 1973). We investigated (1) the correlation between the amount of EA and the growth rate of sarcomata induced by different agents, (2) the specificity of EA ascertaining whether they can be demonstrated on cells other than tumoral or embryonic ones and (3) the influence of anti-embryo immunity on tuimour growth
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