Abstract
The tumour specific antigens and tumour associated embryonic antigens expressed on chemically induced rat hepatomata and sarcomata have been shown to be different by means of blocking antibody studies. Serum from multiparous female rats contained blocking antibody which protected both tumour and embryo cells from the in vitro cytotoxic effect of lymph node cells from multiparous donors. These sera did not, however, block the cytotoxicity of lymph node cells from tumour immune rats for cells of the immunizing tumour. In addition, the tumour specific rejection antigens and embryonic antigens have been shown to have dissimilar locations in tumour cells.
Highlights
Summary.-The tumour specific antigens and tumour associated embryonic antigens expressed on chemically induced rat hepatomata and sarcomata have been shown to be different by means of blocking antibody studies
These tumours express neoantigens at the cell surface which are normally present only on embryo cells during foetal development and are immunogenic in the adult host (Baldwin, Glaves and Pimm, 1971b; Baldwin, Glaves and Vose, 1972b, c; Baldwin et al, 1972a). This raises the possibility that the so-called " tumour specific rejection antigens " are, re-expressed embryonic antigens. This hypothesis has been advanced in studies with hamster cells transformed with SV40 and adenovirus 31 where immunization with irradiated embryo cells can produce immunity against transplanted tumour cells (Coggin, Ambrose and Anderson, 1970; Coggin et al, 1971)
Since the embryonic antigens detected on chemically induced rat tumours are cross-reacting (Baldwin et al, 1972b) and the tumour rejection antigens are specific for each individual tumour, it seems unlikely that this is the case
Summary
Blocking of multiparous donor lymph node cell cytotoxicity by multiparous sera Lymph node cells from multiparous rats were cytotoxic for hepatoma D23 cells and, as shown in Table I, this cytotoxicity was abrogated by pre-exposure of plated tumour cells to heat inactivated sera from multiparous donors. Blocking of multiparous donor lymph node cell cytotoxicity by multiparous sera Lymph node cells from multiparous rats were cytotoxic for hepatoma D23 cells and, as shown, this cytotoxicity was abrogated by pre-exposure of plated tumour cells to heat inactivated sera from multiparous donors. Six of 11 sera were effective in significantly reducing LNC cytotoxicity producing abrogations of 49.8% to 77.8%. TABLE I.-Blocking of Multiparous Rat Lymph Node Cell Cytotoxicity for Hepatoma D23 Target Cells by Multiparous Rat Sera (MPS)
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