Abstract
Human embryonic aneuploidy may represent one of the final frontiers in assisted reproductive technology (ART), primarily secondary to oocyte aneuploidy. Mammalian oocytes possess unique characteristics predisposing them to much higher rates of aneuploidy than sperm or most somatic cells. Some of these characteristics are age-independent, while others result from reproductive aging and environmental toxicity. A detailed understanding of these properties may lead to novel diagnostic and therapeutic tools designed to detect and prevent oocyte and embryonic aneuploidy, to overcome this ultimate barrier to success in ART.
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