Abstract
Transverse (t)-tubules are deep invaginations of the cardiac myocyte sarcolemma which facilitate rapid, synchronous Ca2+ release and forceful contraction. In our ovine tachypaced model of heart failure (HF), atrial t-tubules are lost and the Ca2+ transient decreased. However, following termination of tachypacing, t-tubule restoration is associated with restoration of the Ca2+ transient. Understanding t-tubule formation, and their loss during disease, may therefore be therapeutically advantageous.
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