Abstract
The influence of cholesterol with various molar fractions on the structure of disialoganglioside (GD1a)/cholesterol mixed micelle was investigated by using synchrotron radiation small-angle X-ray scattering (SR-SAXS). The radius of gyration (Rg) of the micelles, estimated from the obtained data, was increased with increasing cholesterol content. A multi-shell model analysis for micelles, that was successfully applied to the structure estimation of GD1 micelles by Hirai et al. (1996), revealed that the cholesterol-dependent increase of Rg of the micelles is due to an elongation of its prolate spherocylindrical structure. In the present analysis, we assumed the micelle of the ganglioside/cholesterol mixture as a triple-shell structure taking into account the high electron density of the steroid ring of cholesterol that is inserted in the hydrophobic region of the micelle. The examined molar ratios of [ganglioside]/[cholesterol] were 1:0, 1:0.05, 1:0.1, 1:0.2, 1:0.4, 1:0.7 and 1:1. The ganglioside concentration for all samples was constant at 0.5 % w/v.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
