Ellagik Asidin Çekal Ligasyon ve Delmeye Bağlı Akciğer Hasarı Üzerine Etkileri

Abstract

Ellagic acid was examined on lung tissue injury caused by cecal ligation and puncture (CLP)-induced polymicrobial sepsis model in rats. 24 Wistar Albino female rats were allocated to 3 groups as: Group I (Sham), group II (CLP), and group III (CLP+ Ellagic acid 75 mg/kg). The CLP model was made by drilling the cecum. Biochemical and immunohistochemical analyzes were performed. Total oxidant status, tumor necrosis factor-α, interleukin-1β, malondialdehyde, and myeloperoxidase activity elevated, but superoxide dismutase and total antioxidant status valued declined in the CLP group compared to the sham group. On the contrary, superoxide dismutase and total antioxidant status levels increased. In contrast, myeloperoxidase activity, total oxidant status, tumor necrosis factor-α, interleukin-1β, and malondialdehyde levels decreased in the Ellagic acid treatment group. Caspase-3 and microtubule-associated protein light chain-3B immunopositivity increased significantly in the CLP group compared to the sham group while diminishing in the Ellagic acid group. In conclusion, Ellagic acid prevented CLP-induced lung injury in experimental rats. Thus, Ellagic acid may be an alternative therapeutic agent against lung tissue injury induced by sepsis.