ELF-EMF'in Beyin, Karaciğer ve Kalp Dokularında Oksidatif Parametreler Üzerine Etkilerinin Değerlendirilmesi

Abstract

The aim of the present study was to investigate the prospective effects of continuous and intermittent extremely low-frequency magnetic fields (ELF-EMFs) on the levels of malondialdehyde (MDA), nitric oxide (NO) and glutathione (GSH) in brain, heart, and liver tissues. The experiments performed on 18 guinea pigs were divided into three groups (n= 6 for each group). 50 Hz of 1.5 mT a magnetic field was used for exposure. Experimental groups were exposed for 4 h/day either continuously or intermittently (2h on/ 2h off/ 2h on) EMF for a period of 7 days. MDA, NO and GSH levels were determined by spectrophotometric methods. The intermittent exposure was increased GSH levels whereas that was reduced MDA levels in the brain when compared to control and continuous exposure groups. GSH concentrations of both experimental groups were found to be elevated in the liver. In the liver and heart, NO levels were increased by the continuous exposure in both administration groups, however, intermittent exposure has reduced NO levels in the both of the experimental groups. Results of this study indicated that the responses of various tissues to magnetic field exposures differed according to intensity and exposure duration of magnetic fields.