Abstract
On a system-theoretical basis, the phenomenon of “biological resonance” can be described with a genetically structured model. The cell's protein regulation system is stimulated by external attraction with alternating periods of substrate supply and starvationto increase the enzyme synthesis rate (integral mean value), which leads to a higher concentration level compared to the synthesis rate under steady-state conditions. Maximal synthesized enzyme concentration depends on substrate supply and subsequent starvation periods and occurs both at coordinative and sequential inductions. Sequential induction is characterized by a considerably larger increase in the enzyme synthesis rate compared to coordinative induction, presumably because of the longer time delays between induction procedures and repression mechanisms. The simulations performed in this study by varying flow rate and substrate/inductor concentrations illustrate these to be additional parameters able to influence and optimize the phenomenon of biological resonance.Coordinative induction shows relatively insensitive behavior compared to these process parameters. However, the sequential induction rate can be influenced by both parameters and provides a basis for additional optimization of the microbial protein induction rate.
Published Version
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