Abstract
Background. This study investigated an association between systemic absolute neutrophil count (ANC) and albuminuria in elderly Chinese people. Methods. A cross-sectional study was conducted on 2265 participants attending a routine medical examination in Minhang District as part of a Platform of Chronic Disease program. Their drug history, waist circumference, height, blood pressure, fasting blood glucose, ANC, and urine albumin levels were recorded. This study conformed to the requirements of the STROBE statement. Results. Of the 2265 subjects, 1254 (55.4%) were diabetic and 641 (28.3%) had albuminuria. The mean ANC of patients with diabetes comorbid with macroalbuminuria was significantly higher than that of both the nondiabetic patients and patients with diabetes with lower levels of albuminuria; the latter 2 groups had statistically similar ANC. ANC significantly and positively correlated with levels of urine albumin. Based on multivariate analysis, with each 109/L increase in ANC, the increase in rates of macroalbuminuria was significant but not in rates of albuminuria positivity. Based on areas under the receiver operating characteristic curve, ANC was the strongest factor predicting macroalbuminuria. Conclusions. Elevated ANC was associated with macroalbuminuria in diabetes, indicating that neutrophil-mediated inflammation may be involved in the exacerbation of albuminuria.
Highlights
Albuminuria is defined as an abnormally high amount of albumin in the urine and is a strong sign of early renal damage [1,2,3,4]
Compared with the 1011 participants who were free of diabetes, the 1254 participants with diabetes were older, with a higher prevalence of hypertension and increased systolic blood pressure (SBP), absolute neutrophil count (ANC), white blood cell (WBC), ANC/WBC, and fasting blood glucose (FBG)
The 641 participants testing positive for UA creatinine ratio (UACR) (UA+) were older, with higher Body mass index (BMI) and waist-to-hip ratio, SBP, diastolic blood pressure (DBP), serum creatinine (SCr), ANC, WBC, and ANC/WBC compared with the 1624 persons testing negative for UACR (UA−)
Summary
Albuminuria (i.e., urinary albumin, or UA) is defined as an abnormally high amount of albumin in the urine and is a strong sign of early renal damage [1,2,3,4]. In diabetic subjects with albuminuria, no differences in C-reactive protein levels (a marker of inflammation) were observed compared with healthy controls [14]. Serum levels of sialic acid, another marker of inflammation, correlated with increasing albumin excretion [15]. A cross-sectional study was conducted on 2265 participants attending a routine medical examination in Minhang District as part of a Platform of Chronic Disease program. Their drug history, waist circumference, height, blood pressure, fasting blood glucose, ANC, and urine albumin levels were recorded. Elevated ANC was associated with macroalbuminuria in diabetes, indicating that neutrophil-mediated inflammation may be involved in the exacerbation of albuminuria
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
