Abstract
BackgroundThis retrospective observational study aims to assess platelet count, mean platelet volume (MPV), blood biochemical tests for liver and kidney function in Chinese oral lichen planus (OLP) patients.MethodsEighty pathologically confirmed OLP patients and 51 healthy controls were enrolled. Data on full blood count and biochemical tests were obtained from the electronic medical record system of the hospital.ResultsMPV was elevated in OLP patients compared to controls (10.68 ± 0.97 fL versus 10.33 ± 0.89 fL, P = 0.042) while platelet count showed no difference between them. Red-form OLP group had increased blood urea nitrogen (BUN, 5.24 ± 1.15 mmol/L versus 4.69 ± 0.98 mmol/L, P = 0.036) than white-form OLP group. By contrast, there were no differences between those two groups in the other variables including MPV, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and creatinine. In terms of C-reactive protein (CRP), 92.5% of the OLP patients had a value of less than 3.48 mg/L. Besides, 75% of the OLP patients were overweight with body mass index (BMI) more than 25 kg/m2.ConclusionsThese findings indicate MPV might play roles in inflammation in OLP. The red-form OLP might be associated with damage or reduction of kidney function.
Highlights
This retrospective observational study aims to assess platelet count, mean platelet volume (MPV), blood biochemical tests for liver and kidney function in Chinese oral lichen planus (OLP) patients
The related diseases encompassed atherosclerotic disease (n = 2, 1.82%), blood disorder (n = 56, 50.91%), cancer (n = 3, 2.73%), infection (n = 6, 5.45%), inflammation (n = 8, 7.27%) and metabolic syndrome (n = 35, 31.82%). Since all those systemic diseases could alter blood counts and/or liver and kidney function, we excluded them from this study
In this study, we found that elevated Mean platelet volume (MPV) in Chinese patients with OLP despite no significant difference in platelet count
Summary
This retrospective observational study aims to assess platelet count, mean platelet volume (MPV), blood biochemical tests for liver and kidney function in Chinese oral lichen planus (OLP) patients. Oral lichen planus (OLP) is a chronic T-lymphocyte mediated inflammatory disorder, which presents in two primary clinical categories: white forms (reticular, papular, plaquelike) and red forms (erosive, atrophic, bullous) [1]. It is one of the most common diseases in oral medicine clinics. Mean platelet volume (MPV) represents the average size of platelet, reflects the platelet stimulation and production rate, and indicates the platelet function and activation for inflammation [7]. Chronic inflammation is the cause of secondary injury to organs gradually, including liver and kidney, possibly via inducing oxidative stress [9]
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