Abstract
BackgroundDeregulation of glycemic and glycated hemoglobin (HbA1) levels accelerate the progression of cardiovascular complications in type 1 diabetes mellitus (T1DM). The aim of this study was to investigate the association between HbA1 and changes in blood pressure of children and adolescents with T1DM.MethodsA total of 60 children and adolescents were recruited and allocated into two groups (prehypertension and control group). Blood pressure and HbA1 were measured by the oscillometric method and high-performance liquid chromatography, respectively.ResultsThe prehypertensive group had (P < 0.05) higher disease duration, body weight, Z score for body weight, systolic blood pressure (SBP), diastolic blood pressure (DBP) and a higher HbA1 when compared with the control children and adolescents. Multiple regression to predict alterations in DBP from HbA1 adjusted for age, disease duration, and body mass index demonstrated a positive relationship with DBP (P < 0.05). A 1 % increase in HbA1 was associated with 1.73 mmHg increase in DBP.ConclusionsHigh levels of HbA1 may be associated with increased blood pressure in T1DM. A tight control of HbA1 levels may provide long-term cardiovascular protection in children and adolescents with T1DM.
Highlights
Deregulation of glycemic and glycated hemoglobin (HbA1) levels accelerate the progression of cardiovascular complications in type 1 diabetes mellitus (T1DM)
Results revealed a positive correlation of systolic blood pressure (SBP) and diastolic blood pressure (DBP) with age and body mass index (BMI), while diabetes duration was only correlated with DBP
The prehypertensive group demonstrated significantly higher T1DM disease duration, body weight, Z score body weight, SBP, DBP and HbA1 as compared with the normotensive group of children and adolescents with T1DM, no differences were verified for BMI z-score (Table 1)
Summary
Deregulation of glycemic and glycated hemoglobin (HbA1) levels accelerate the progression of cardiovascular complications in type 1 diabetes mellitus (T1DM). The aim of this study was to investigate the association between HbA1 and changes in blood pressure of children and adolescents with T1DM. Children with T1DM and hypertension present higher pulse pressure and ambulatory stiffness index levels when compared with normotensive patients [1]. Elevated values of blood pressure (BP) in children with T1DM are associated with an increased risk for developing cardiovascular complications later in life [1]. Glycated hemoglobin (HbA1) was correlated with BMI, this parameter was not used as a main factor to predict BP elevation de Oliveira et al Diabetol Metab Syndr (2016) 8:4 in T1DM adolescents, which could be a more sensible indicator as compared with BMI. It seems reasonable to investigate the association of different HbA1 ranges with BP values in T1DM in children and adolescents
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