Elevated Bilirubin Level Increase the Risk of Gallstone Disease in Pediatric Hereditary Spherocytosis Patients: A Case Report

Abstract

Disorders of gall bladder are common and remain as one of the main patients’ chief complaints that might lead to surgical interventions. High level of bilirubin causes gallstones in patients with hereditary spherocytosis (HS). It is often misdiagnosed, because these deposits of bilirubin can be easily broken down in the gallbladder. Gallstones develop in less than half of patients with mild HS and do not always cause symptomatic biliary tract disease. HS is a genetic defect in red blood cells, caused by defects in structural membrane proteins. It is characterized by a decrease the surface area to volume ratio in erythrocytes due to the heterogeneous changes in the various genes that encode for proteins. A 14-year old male was brought to Medical Park hospital/Turki at the emergency room with a sudden onset of pain in the right upper quadrant, vomiting, anemia and jaundice. The patient was diagnosed with gallstone due to obstruction in common bile duct (CBD),with elevated bilirubin as a result for mild HS. This case report study highlight on the role of hereditary spherocytosis in forming many abdominal problem such as gallstone due to high level of heamolysis and elevated of bilirubin. How to Cite this Article Pubmed Style Najlaa Abdulameer Ali Al-Dahhan, Hawraa Abdulameer Ali Al-Dahhan, Bayan Jebur Hussein. Bilirubin Level Increase the Risk of Gallstone Disease in Pediatric Hereditary Spherocytosis Patients: A Case SRP. 2020; 11(6): 341-346. doi:10.31838/srp.2020.6.54 Web Style Najlaa Abdulameer Ali Al-Dahhan, Hawraa Abdulameer Ali Al-Dahhan, Bayan Jebur Hussein. Bilirubin Level Increase the Risk of Gallstone Disease in Pediatric Hereditary Spherocytosis Patients: A Case http://www.sysrevpharm.org/?mno=116258 [Access: March 29, 2021]. doi:10.31838/srp.2020.6.54 AMA (American Medical Association) Style Najlaa Abdulameer Ali Al-Dahhan, Hawraa Abdulameer Ali Al-Dahhan, Bayan Jebur Hussein. Bilirubin Level Increase the Risk of Gallstone Disease in Pediatric Hereditary Spherocytosis Patients: A Case SRP. 2020; 11(6): 341-346. doi:10.31838/srp.2020.6.54 Vancouver/ICMJE Style Najlaa Abdulameer Ali Al-Dahhan, Hawraa Abdulameer Ali Al-Dahhan, Bayan Jebur Hussein. Bilirubin Level Increase the Risk of Gallstone Disease in Pediatric Hereditary Spherocytosis Patients: A Case SRP. (2020), [cited March 29, 2021]; 11(6): 341-346. doi:10.31838/srp.2020.6.54 Harvard Style Najlaa Abdulameer Ali Al-Dahhan, Hawraa Abdulameer Ali Al-Dahhan, Bayan Jebur Hussein (2020) Bilirubin Level Increase the Risk of Gallstone Disease in Pediatric Hereditary Spherocytosis Patients: A Case SRP, 11 (6), 341-346. doi:10.31838/srp.2020.6.54 Turabian Style Najlaa Abdulameer Ali Al-Dahhan, Hawraa Abdulameer Ali Al-Dahhan, Bayan Jebur Hussein. 2020. Bilirubin Level Increase the Risk of Gallstone Disease in Pediatric Hereditary Spherocytosis Patients: A Case Systematic Reviews in Pharmacy, 11 (6), 341-346. doi:10.31838/srp.2020.6.54 Chicago Style Najlaa Abdulameer Ali Al-Dahhan, Hawraa Abdulameer Ali Al-Dahhan, Bayan Jebur Hussein. Elevated Bilirubin Level Increase the Risk of Gallstone Disease in Pediatric Hereditary Spherocytosis Patients: A Case Report. Systematic Reviews in Pharmacy 11 (2020), 341-346. doi:10.31838/srp.2020.6.54 MLA (The Modern Language Association) Style Najlaa Abdulameer Ali Al-Dahhan, Hawraa Abdulameer Ali Al-Dahhan, Bayan Jebur Hussein. Elevated Bilirubin Level Increase the Risk of Gallstone Disease in Pediatric Hereditary Spherocytosis Patients: A Case Report. Systematic Reviews in Pharmacy 11.6 (2020), 341-346. Print. doi:10.31838/srp.2020.6.54 APA (American Psychological Association) Style Najlaa Abdulameer Ali Al-Dahhan, Hawraa Abdulameer Ali Al-Dahhan, Bayan Jebur Hussein (2020) Bilirubin Level Increase the Risk of Gallstone Disease in Pediatric Hereditary Spherocytosis Patients: A Case Systematic Reviews in Pharmacy, 11 (6), 341-346. doi:10.31838/srp.2020.6.54