Abstract
A facile and efficient ring opening of isatin has been achieved by electrochemical anodic oxidation directly at room temperature. The results show that a constant current electrolysis of isatins in an undivided cell affords both the ester group and the urea group simultaneously. This reaction opens a new avenue for the synthesis of methyl 2-ureidobenzoates, enriches the research on the reactions of isatins involving the cleavage of the C2–C3 bond and shows a good range of substrates for both isatin and simple organic amine in an acidic buffer solutions of HOAc and Cu(OAc)2. In addition, this electrochemical C2–C3 bond cleavage reaction could be scaled up.
Published Version
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