Abstract
Copolymer solution of vinylidene fluoride with tetrafluoroethylene (VDF-TeFE) was used for electrospinning of fluoropolymer scaffolds. Magnetron co-sputtering of titanium and copper targets in the argon atmosphere was used for VDF-TeFE scaffolds modification. Scanning electron microscopy (SEM) showed that scaffolds have a nonwoven structure with mean fiber diameter 0.77 ± 0.40 μm, mean porosity 58 ± 7%. The wetting angle of the original (unmodified) hydrophobic fluoropolymer scaffold after modification by titanium begins to possess hydrophilic properties. VDF-TeFE scaffold modification by titanium/copper leads to the appearance of strong antibacterial properties. The obtained fluoropolymer samples can be successfully used in tissue engineering.
Highlights
Copolymer of vinylidene fluoride with tetrafluoroethylene (VDF-TeFE) has high chemical and thermal resistance, ability to dissolve in organic solvents [1] and piezoelectric properties [2]
The aim of this work is the manufacture of VDF-TeFE scaffolds, modified by copper aureus (MRSA) for tissue engineering needs
Plasma modification of scaffolds in various modes allows the preservation of the pristine surface morphology
Summary
Copolymer of vinylidene fluoride with tetrafluoroethylene (VDF-TeFE) has high chemical and thermal resistance, ability to dissolve in organic solvents [1] and piezoelectric properties [2]. Biocompatible piezoelectric fluoropolymers are actively used in the manufacture of tissue-engineered scaffolds [4]. The electrospinning method is actively used in polymeric scaffold production for tissue engineering needs [5]. Electrospinning materials are characterized by relatively high mechanical properties and biocompatibility. This is due to the possibility of manufacturing fibers from 10 nm to 10 μm [6], with extremely high surface area [5] and the ability to imitate the topology of extracellular matrix [7]
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