Abstract
New strategies based on complex nanostructures for developing advanced functional materials providing sustained release of loaded active ingredients are highly desired in various scientific fields. In the present study, a new strategy was proposed to prepare a trilayer nanodepot, in which a drug reservoir was built into a core–shell nanofiber. A modified triaxial electrospinning was implemented to prepare the trilayer depots F2 using cellulose acetate and acyclovir as polymer matrix and active ingredient, respectively. For comparison, a core–shell nanofiber F1 with a blank polymer coating on a drug-loaded nanocomposite was created using a modified coaxial electrospinning. Although nanofibers F1 and nanodepots F2 had the same drug and polymeric components and similar linear morphologies, they exhibited considerably differences in providing the drug-sustained release profiles. Trilayer depots F2 could manipulate a better drug-sustained release profile with a small tailing-off time period. This finding is attributed to the change in drug diffusion mechanism. A constant diffusion distance from a saturated drug reservoir ensured a controllable drug-sustained release rate and a quick late drug exhaustion from trilayer nanodepots. The proposed strategy serves as a new method for developing process–structure–performance relationships at nanoscale for functional applications.
Published Version
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