Electrospun polymeric dressings functionalized with antimicrobial peptides and collagen type I for enhanced wound healing

H P Felgueiras,M T P Amorim

doi:10.1088/1757-899x/254/6/062004

H P Felgueiras, M T P Amorim

Open Access

https://doi.org/10.1088/1757-899x/254/6/062004

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Abstract

Modern wound dressings combine medical textiles with active compounds that stimulate wound healing while protecting against infection. Electrospun wound dressings have been extensively studied and the electrospinning technique recognized as an efficient approach for the production of nanoscale fibrous mats. The unique diverse function and architecture of antimicrobial peptides (AMPs) has attracted considerable attention as a tool for the design of new anti-infective drugs. Functionalizing electrospun wound dressings with these AMPs is nowadays being researched. In the present work, we explore these new systems by highlighting the most important characteristics of electropsun wound dressings, revealing the importance of AMPs to wound healing, and the methods available to functionalize the electrospun mats with these molecules. The combined therapeutic potential of collagen type I and these AMP functionalized dressings will be highlighted as well; the significance of these new strategies for the future of wound healing will be clarified.

Highlights

Wound dressing design and fabrication are important segments of the textile medical and pharmaceutical wound care market worldwide
We reviewed the basic concepts associated with electrospinning technique and explored the use of antimicrobial peptides (AMPs) in wound healing
Perspectives Due to the continue rising of antimicrobial resistant pathogens, the need for engineered alternated treatments for acute to chronic wound care has increased

Summary

Introduction

Wound dressing design and fabrication are important segments of the textile medical and pharmaceutical wound care market worldwide. Electrospinning has become one of the most popular processes to produce medical textiles in the form of wound dressings This is a simple and effective method to produce nanoscale fibrous mats with controlled pore size and structure, from both natural and synthetic origin polymers. This technique has gain much attention because of its versatility, reproducibility, volume-to-surface ratio and submicron range [2,3,4]. Functionalizing these electrospun wound dressings with active compounds that accelerate wound healing and tissue regeneration has become the major goal [5]. Nanofibrous mats produced by eletrospinning may accommodate all these demands

Technique

Findings

Conclusions and Future Perspectives