Electrospun Poly(L-Lactide-co-ε-Caprolactone)/Polyethylene Oxide/Hydroxyapaite Nanofibrous Membrane for Guided Bone Regeneration

Gang Wang,Chunhong Cao,Tianbin Ren,Ying Song,Jiansheng Su,Weizhong Yuan

doi:10.1155/2010/232017

Abstract

A series of poly(L-lactide-co-ε-caprolactone)/polyethylene oxide/hydroxyapaite (PLCL/PEO/HA) composite fibrous membranes were prepared by elecrospinning technology for guided bone regeneration. The morphology, water permeability and mechanical properties of the membranes were investigated. The HA nanocrystals can be well distributed in the PLCL/PEO matrix. And the diameter of composite nanofiber is larger than that of pure PLCL. The fibers with uniform size and large diameter were obtained when the contents of PEO and HA were 0.4% and 0.03%, respectively. In this condition, the obtained membrane presents the best water permeability. Furthermore, the nanofibrous membrane with largest tensile strength was obtained when the contents of PEO and HA were 0.5% and 0.03%, respectively.

Highlights

Guided bone regeneration membranes (GBRMs) are able to promote bone repair for their physical barrier function, separating defects with surrounding tissues and creating necessary growth spaces to bone
Considerable attention has been paid on GBRMs for the applications in biomedical field [1,2,3]
The nonbioabsorbable GBRMs have to be removed by secondary surgical procedures after new bone regeneration

Summary

Introduction

Guided bone regeneration membranes (GBRMs) are able to promote bone repair for their physical barrier function, separating defects with surrounding tissues and creating necessary growth spaces to bone. Considerable attention has been paid on GBRMs for the applications in biomedical field [1,2,3]. The nonbioabsorbable GBRMs have to be removed by secondary surgical procedures after new bone regeneration. The bioabsorbable GBRMs are more and more widely researched and applied for avoiding secondary surgery to alleviate patients’ sufferings and limit risks of tissue infection [11,12,13,14]. The natural bioabsorbable GBRMs are usually lack excellent mechanical performance and degraded rapidly which hinder bone recovery. Developing of new GBRMs composed of synthetic polymeric materials, such as polyester, or their composites with inorganic materials which have good osteoconductivity, is attracting more and more attention [15,16,17,18]

Methods

Results

Conclusion