Abstract
A novel electrochemiluminescence (ECL) sensor for glucose detection was constructed by covering Au nanoparticles (Au NPs), Ni metal–organic frameworks nanofibers (Ni-MOF NFs) and glucose oxidase (GOD) on the electrode surface, respectively. Ni-MOF NFs prepared by electrostatic spinning can be used as GOD carrier and ECL promoter. Meanwhile, synergistic effect of Ni-MOF NFs and Au NPs could amplify the ECL signal of Ru(bpy)32+-TPrA system. With the increasing of glucose concentration, ECL signal was also increasing, so a method for determining glucose could be established. The possible mechanism of luminescence was investigated, and the parameters affecting the experimental reaction were also studied. Under the optimal conditions, the constructed ECL sensor can effectively detect glucose in the range of 2.0 × 10−10 to 2.0 × 10−5 M, and the detection limit was 6.7 × 10−11 M. This study demonstrated for the first time that Ni-MOF NFs could serve as ECL accelerator for the facile detection of glucose in human serum.
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