Abstract
Pharmaceutical nano-fibers have attracted widespread attention from researchers for reasons such as adaptability of the electro-spinning process and ease of production. As a flexible method for fabricating nano-fibers, electro-spinning is extensively used. An electro-spinning unit is composed of a pump or syringe, a high voltage current supplier, a metal plate collector and a spinneret. Optimization of the attained nano-fibers is undertaken through manipulation of the variables of the process and formulation, including concentration, viscosity, molecular mass, and physical phenomenon, as well as the environmental parameters including temperature and humidity. The nano-fibers achieved by electro-spinning can be utilized for drug loading. The mixing of two or more medicines can be performed via electro-spinning. Facilitation or inhibition of the burst release of a drug can be achieved by the use of the electro-spinning approach. This potential is anticipated to facilitate progression in applications of drug release modification and tissue engineering (TE). The present review aims to focus on electro-spinning, optimization parameters, pharmacological applications, biological characteristics, and in vivo analyses of the electro-spun nano-fibers. Furthermore, current developments and upcoming investigation directions are outlined for the advancement of electro-spun nano-fibers for TE. Moreover, the possible applications, complications and future developments of these nano-fibers are summarized in detail.
Highlights
As one-dimensional nano materials, nano-fibers have attracted a lot of attention from researchers and found widespread applications [1]
They encapsulated the bovine serum albumin (BSA) into the microspheres and demonstrated that Bovine Serum Albumin (BSA) was generated from nano-fibers with lengthy periods of release pattern and less rapid release rates compared with the bare Ca-alginate microspheres [107]
Nano-fiber technology advances permit the fabrication of nano-fibers from a wide
Summary
As one-dimensional nano materials, nano-fibers have attracted a lot of attention from researchers and found widespread applications [1]. In bottom-up methods such as electro-spinning, drawing, self-assembly, template synthesis, and phase separation, nano-fibers are fabricated from constituting molecules Due to their distinctive features that make them quite appropriate for drug delivery systems and biomedical engineering, nano-fibers have been the target of attention of many scientists and researchers [6,7]. As an outstanding cost-efficient EHD method, electro-spinning has found vast applications in the industry and laboratory for fiber fabrication In this method, pharmaceutical biomolecules or agents are directly encapsulated within the fibers, leading to their protection from the environmental parameters and, simultaneously, to the release control [5].
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