Abstract
Five commercial dimethylated β-cyclodextrin (DM-β-CD) samples were analysed by electrospray (or ionspray) mass spectrometry (ESI-MS) and supercritical fluid chromatography (SFC) with evaporative light scattering detection. A silica and a nitro-bonded silica were selected using CO 2–methanol–acetonitrile–water and CO 2–methanol as mobile phase, respectively. An extensive optimisation scheme was performed for mobile phase selection. Both SFC systems were used for analyses of complex DM-β-CD samples. Peak identifications were made using off-line ESI-MS. Commercial DM-β-CDs are impure mixtures of homologues and isomers and analysis reveals that every manufacturer produces a different mixture.
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