Abstract
The activity of 67 nonpyramidal neurons from the str. radiatum moleculare (NSRM) and 8 presumed interneurons of str. orienspyramidale (NSOP) was recorded in guinea pig hippocampal slices. In contrast with the high frequency grouped discharges characteristic of NSOP, NSRM had low frequency background activity consisting of a single action potential (77%) and grouped spikes (23%). The spontaneous firing rate of neurons of the radial layer decreased with increasing distance from the pyramidal layer. NSRM responded with one or two action potentials rather than a burst of spikes to electrical stimulation of the dentate fascia. The threshold of response for NOSP was lower, while that of NSRM was the same on average but was significantly higher than for NSOP on a number of occasions. The response of both types of neuron was usually accompanied by an inhibitory pause. During induced epileptoid activity single or grouped discharges arose in neurons of both types concurrently with synchronized bursts in the pyramidal cells. It is postulated that NSOP exert an excitatory effect on NSRM.
Published Version
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