Electrophysiological evidence of impaired cognitive reappraisal in amnestic mild cognitive impairment: An event-related potential study

Abstract

BackgroundEmotion dysregulation symptoms are associated with higher conversion rates from MCI to dementia. Thus, understanding the neural mechanism underlying emotion regulation in people with MCI could provide useful information in early detection and intervention of MCI. This study investigated cognitive reappraisal, an emotion regulation strategy, in people with MCI using event-related potentials analysis. MethodsLate positive potential (LPP) was measured in 46 amnestic MCI subjects and 47 healthy elderly controls (HECs) as they viewed neutral and unpleasant images. All participants viewed a brief description of the upcoming image; neutral images were neutrally described (the Neut condition), and negative images were preceded with either more neutral (the Rea condition) or more negative (the Neg condition) interpretations. ResultsMCI subjects reduced their emotional intensity to a smaller extent than HEC subjects. For MCI subjects, the decreased level of emotional intensity was positively correlated with function in the verbal and executive domains. The reduced intensity (Rea - Neg) was also inversely correlated with the LPP difference (Rea - Neg) 3600–5000 ms after stimulus onset. Compared with HEC subjects, MCI subjects showed hypoactivation in the cuneus in the N2 time range (240–310 ms) and in the inferior parietal lobule and supramarginal gyrus in the 3600–5000 ms range. ConclusionThese results suggest that MCI subjects failed to maintain the reappraisal of negative stimuli in the late time window, which contributed to a smaller success with reappraisal.