P1‐227: DEFICITS IN EXECUTIVE FUNCTION IN AMNESTIC MILD COGNITIVE IMPAIRMENT: EVENT‐RELATED POTENTIALS STUDY DURING STROOP COLOR‐WORD TASK

Abstract

Previous investigations showed that Alzheimer's disease (AD)-related executive function deficits start near the beginning of mild cognitive impairment (MCI) phase of itself. The study aimed to explore deficits in executive function in amnestic MCI (aMCI) with Event-Related Potentials (ERPs) study. The ERP data were measured and analyzed in 30 aMCI and 38 healthy elderly controls (HEC) during Stroop Color-Word Task (SCWT). The study indicated that aMCI patients showed decreased accuracy (ACC) and delayed reaction time (RT) in incongruent condition, compared to HEC (all p < 0.05). Additionally, aMCI patients showed greater N450 amplitudes of a difference wave between ERPs elicited by incongruent and congruent stimuli at Fz electrode, compared to HEC (all p < 0.05). Moreover, standardized low-resolution brain electromagnetic tomography analysis (sLORETA) study showed a hyperactivation in the left inferior parietal lobule (IPL) in the contrast for the incongruent condition relative to the congruent condition, compared to HEC during N450 time range (p < 0.05). The study showed deficits in conflict processing in aMCI with an ERP study. And the deficits might derive from the left IPL. Hence, the study demonstrated that ERP with SCWT was a sensitive biomarker for recognizing aMCI patients from HEC.