Abstract
Cortical steady potential shifts were recorded in both anesthetized and chronic rats during cortical spreading depression. Unilateral application of 12 or 25% KC1 evoked steady potential shifts not only in the hemisphere which received KC1 but also in the contralateral hemisphere. In some cases these steady potential shifts in the contralateral hemisphere resembled the shifts in the depressed hemisphere, while in other cases only part of the wave form of the depressed hemisphere was observed in the contralateral hemisphere. Application of saline by means of pledgets or by direct injection into chronically implanted cannulae did not terminate steady potential shifts. The application of these findings to behavioral research utilizing the technique of spreading depression is discussed.
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