Abstract
The action of cortisone on the neuromuscular apparatus was studied in situ in experiments on rats. Combined recordings were made of the action potentials of nerve (APn) and muscle (APm) and also of intracellular resting membrane potentials (MP) and miniature end-plate potentials (MEPP). Cortisone was injected in a dose of 1.5 mg/100 g body weight daily for 10 days. In the animals receiving the hormone, MP of the muscle fibers was reduced compared with the control, the amplitude of the MEPP was reduced and their frequency increased, the time of neuromuscular transmission was lengthened, and its reliability was reduced (the amplitude of APm fell faster in the course of tetanus).
Published Version
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