Abstract
Gel electrophoretic patterns of nuclear and cytoplasmic ribosomal RNA (rRNA) from livers of intact and adrenalectomized rats were studied after exposure to gamma radiation (1800 rad) and/or 5-fluoroorotic acid (5-FOA) treatment. By 6 hr after either 5-FOA administration alone, or in combination with irradiation, incorporation of (6- 14C )orotic acid into 45S rRNA precursors was elevated because maturation was blocked and appearance of 28S and 18S subunits delayed. By 12 hr post-irradiation the 45S block was firmly established. In adrenalectomized rats 5-FOA administration alone produced a block within 0.5 hr and after 6 hr following exposure to radiation. The results obtained in the current study are consistent with the conclusion that radiation selectively inhibits rRNA maturation in liver cells; and the response is influenced by the presence of adrenal glands.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Radiation Oncology, Biology, Physics
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
